TASCMAR, Tools And Strategies to access to original bioactive compounds from Cultivation of MARine invertebrates and associated symbiots
Start date: 15/04/2015 End date: 15/04/2019 H2020 funding: Total project budget (for the consortium): €6 CHEMBIOPRO funding: €755 Presentation, objective(s): TASCMAR is a project which contributes to the blue growth desired by the European Commission. Its objective was to discover new […]
Start date : 15 / 04 / 2015
End date : 15 / 04 / 2019
H2020 financing :
Total project budget (for the consortium): €6
CHEMBIOPRO financing: €399
Presentation, objective(s):
TASCMAR is a project which contributes to the blue growth desired by the European Commission. Its objective was to discover new bioactive molecules of marine origin for the development of innovative products in the pharmaceutical, cosmetic and nutraceutical fields. Particular emphasis was placed on the use and development of eco-processes for the extraction and production of anti-aging and angiogenesis modulating active ingredients.
To ensure a sustainable supply of biomass and promote the large-scale production of bioactive marine molecules, TASCMAR has also focused on the development of innovative technologies for the cultivation of marine invertebrates and their associated microorganisms. The planned work began with the collections of marine invertebrates and microorganisms already existing in Israel, Spain, Reunion Island (CHEMBIOPRO) and Thailand (sponges, ascidians, soft corals, sea cucumbers, etc.) then continued on new organisms.
Several collection missions have in fact been carried out in the coral reefs and mesophotic waters (between 30 and 100 m deep) in the Eastern zone of the Mediterranean Sea, the Red Sea, and the South-West zone of the Ocean. Indian and Thai coasts. These collections were carried out in compliance with international, European and local laws relating to the management, conservation and exploitation of natural resources. At the end of the collections, a chemical screening (metabolomic approach) and a biological screening (in vitro, in ovo and in vivo tests) allowed the selection of marine invertebrates for an in-depth study of their chemical composition and their micro- organizations. In addition, throughout the project, databases were created in which all the information relating to the marine invertebrates studied (identification, location, depth and date of collection), the chemistry of these organisms (type of extracts, identification of pure metabolites and isolated biocatalysts, bioactivity of extracts and pure metabolites), associated microorganisms (identification, culture, production of secondary metabolites). CHEMBIOPRO is particularly focused on promoting the marine biodiversity of the South-West zone of the Indian Ocean.
The researchers in this laboratory had the mission of:
- The collection of marine invertebrates and associated microorganisms in the South-West zone of the Indian Ocean (Mayotte, Rodrigues).
- The study of the chemical composition of the collected invertebrates.
- Isolation, identification and culturing of associated microorganisms.
- Characterization of the production of bioactive secondary metabolites by cultured microorganisms.
The partners of the operation
- ICSN (Institute of Chemistry of Natural Substances of Gif-sur-Yvette), CNRS, France
- UoA (National and Kapodistrian University of Athens), Greece
- TAU (Tel Aviv University), Israel
- NSTDA (National Science and Technology Development Agency), Thailand
- CHEMBIOPRO (Laboratory of Chemistry and Biotechnology of Natural Products), University of La Réunion, France.
- I2C (Ideas to Candidates Industry), SME, Germany
- BICT (Bioindustry Innovation Industry), SME, Italy
- PGT (Pierre Guerin Technologies) Industry, France
- IMARE (Natural SL Industry), SME, Spain
- ASTAREAL AB INDUSTRY SME, Sweden
- APIVITA INDUSTRY, SME, SME Greece
- T6ECO (T6 Ecosystems SRL Consulting), SME, Italy
- ECOOCEAN NGO, Israel